Group of college students goes out of town to have fun in full over the weekend: drink beer, go for a swim in the lake and breathe the fresh forest air. But on the first day they encounter uncouth farmers Tucker and Dale, who also have decided how to have fun in nature. By taking these wild, but, in fact, pretty boys for "malicious local people", the townspeople decide to give a tough resistance to the hillbillies. But with every their move it only gets worse...