Megamind is the most brilliant and unfortunate villain in the world. For many years he has been trying to seize Metro City in all possible ways, but each attempt failed because of a superhero named Metro Man. When Megamind kills Metro Man he loses a purpose of his life. A supervillain without a superhero. The only way to live a happy life is to create a new superhero Titan. Titan comes to a conclusion that being a villain is more interesting, but he is not interested in ruling the world, but in destroying it. Megamind faces a difficult choice. Will the evil genius become the saviour of mankind?